SrasV1, 2020, Analysis, bibRecord, 000104

Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond.

Identifieur interne : 000104 ( 2020/Analysis ); précédent : 000103; suivant : 000105

Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond.

Auteurs : Sean Ekins [États-Unis] ; Thomas R. Lane [États-Unis] ; Peter B. Madrid [États-Unis]

Source :

Pharmaceutical research [ 1573-904X ] ; 2020.

RBID : pubmed:32215760

Descripteurs français

KwdFr :
- Animaux, Antiviraux (pharmacologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Ebolavirus (), Humains, Infections à coronavirus (traitement médicamenteux), Marburgvirus (), Pandémies, Pneumopathie virale (traitement médicamenteux), Tilorone (pharmacologie), Virus du chikungunya ().
MESH :
- pharmacologie : Antiviraux, Tilorone.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Ebolavirus, Humains, Marburgvirus, Pandémies, Virus du chikungunya.

English descriptors

KwdEn :
- Animals, Antiviral Agents (pharmacology), Betacoronavirus (drug effects), Chikungunya virus (drug effects), Coronavirus Infections (drug therapy), Ebolavirus (drug effects), Humans, Marburgvirus (drug effects), Middle East Respiratory Syndrome Coronavirus (drug effects), Pandemics, Pneumonia, Viral (drug therapy), Tilorone (pharmacology).
MESH :
- chemical , pharmacology : Antiviral Agents, Tilorone.
- drug effects : Betacoronavirus, Chikungunya virus, Ebolavirus, Marburgvirus, Middle East Respiratory Syndrome Coronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- Animals, Humans, Pandemics.

Abstract

For the last 50 years we have known of a broad-spectrum agent tilorone dihydrochloride (Tilorone). This is a small-molecule orally bioavailable drug that was originally discovered in the USA and is currently used clinically as an antiviral in Russia and the Ukraine. Over the years there have been numerous clinical and non-clinical reports of its broad spectrum of antiviral activity. More recently we have identified additional promising antiviral activities against Middle East Respiratory Syndrome, Chikungunya, Ebola and Marburg which highlights that this old drug may have other uses against new viruses. This may in turn inform the types of drugs that we need for virus outbreaks such as for the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Tilorone has been long neglected by the west in many respects but it deserves further reassessment in light of current and future needs for broad-spectrum antivirals.

DOI: 10.1007/s11095-020-02799-8
PubMed: 32215760

Affiliations:

Links to Exploration step

pubmed:32215760

Le document en format XML

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<front><div type="abstract" xml:lang="en">For the last 50 years we have known of a broad-spectrum agent tilorone dihydrochloride (Tilorone). This is a small-molecule orally bioavailable drug that was originally discovered in the USA and is currently used clinically as an antiviral in Russia and the Ukraine. Over the years there have been numerous clinical and non-clinical reports of its broad spectrum of antiviral activity. More recently we have identified additional promising antiviral activities against Middle East Respiratory Syndrome, Chikungunya, Ebola and Marburg which highlights that this old drug may have other uses against new viruses. This may in turn inform the types of drugs that we need for virus outbreaks such as for the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Tilorone has been long neglected by the west in many respects but it deserves further reassessment in light of current and future needs for broad-spectrum antivirals.</div>
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Serveur d'exploration SRAS

Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond.

Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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